Carbapenem mic values for the enterobacteriaceae family according to eucast guidelines antibiotic ertapenem. Pdf ertapenem is a parenteral carbapenem licensed for use in adults and children more than 3 months of age. Ertapenem is a new carbapenem developed to address the pharmacokinetic shortcomings short halflife of imipenem and meropenem. Ertapenem is used to treat severe infections of the skin, lungs, stomach, pelvis, and urinary tract. We evaluated the impact of a carbapenem stewardship program, restricting imipenem and meropenem use. To compare and contrast imipenem and meropenem in terms of in vitro activity, pharmacokinetics, clinical efficacy and adverse effects. Ertapenem is a 1betamethyl carbapenem and broadspectrum betalactam antibiotic with bactericidal property. Efficacy and safety of deescalation therapy to ertapenem for. Bactericidal activities of meropenem and ertapenem against. Carbapenem antibiotics are considered the treatment of choice for serious extendedspectrum betalactamase. Ertapenem shares similar structural features with meropenem. In this phase iii trial comparing eravacycline with ertapenem for complicated intraabdominal infections, eravacycline met both the fda and ema primary end points of noninferior clinical efficacy vs ertapenem. Pubmed, embase, medline via ovid sp and cochrane library databases were systematically searched.
Comparison of in vitro efficacy of ertapenem, imipenem and. Ertapenem, the first of a new group of carbapenems journal of. Ertapenem, imipenem, meropenem, and doripenem are formulated as parenteral agents because they are absorbed poorly after oral ingestion. Compare ertapenem vs meropenem comprehensive analysis by. The clinical efficacy and safety of ertapenem for the. Ertapenem, like imipenem and meropenem, demonstrates. Effect of piperacillintazobactam vs meropenem on 30day. Only ertapenem, imipenem, and meropenem showed 100%. We evaluated the effect of three carbapenems on gut colonization of mice by candida albicans. We compared the activities of the carbapenems ertapenem, meropenem, and imipenem against 180 isolates of rapidly growing mycobacteria rgm and 170 isolates of nocardia using the clinical and laboratory standards institute clsi guidelines. It is also used to prevent infection in people having certain types of surgery. Similar to imipenem and meropenem, ertapenem has a very broad spectrum of antimicrobial activity, including grampositive and gramnegative aerobic and anaerobic pathogens.
Comparative efficacy of doripenem versus meropenem for. We included randomized controlled trials rcts comparing different carbapenems vs tgc for the treatment of ciais. Reserve use whenever possible, as it is one of our lastline antibiotics. It can be given at home, but youll have to be taught how to inject it correctly. Two carbapenems, imipenem and meropenem, have been in clinical use for many years. Carbapenems vs alternative antibiotics for the treatment. Impact of an antimicrobial stewardship initiative on. Network metaanalysis is a useful tool to compare multiple treatments when there is limited or no direct evidence available. Urinary tract infections utis are common and important clinical problem in childhood, and extendedspectrumbetalactamase esbl producing organisms are the leading cause of healthcarerelated utis. Ertapenem resistance of escherichia coli mariefrederique lartigue, laurent poirel, claire poyart, helene reglierpoupet, and patrice nordmann an ertapenem resistant escherichia coliisolate was recovered from peritoneal fluid in a patient who had been treated with imipenemcilastatin for 10 days. All carbapenems have a risk of seizures, which is believed to be associated with their structural similarity with. Anaerobic coverage 1,2 all carbapenems have fairly good coverage against anaerobes. In vitro comparison of ertapenem, meropenem, and imipenem. Compare headtohead ratings, side effects, warnings, dosages, interactions and.
Humansimulated dosing regimens in mice were designed to approximate the free drug percent time above the mic f tmic observed for humans following meropenem at. Chambers, in mandell, douglas, and bennetts principles and practice of infectious diseases eighth edition, 2015. The rate of susceptibility to ertapenem and meropenem was limited and less than that to. Ertapenem may also be used for purposes not listed in this medication guide. The purpose of this study was to examine the in vivo efficacies of meropenem and ertapenem against extendedspectrum. In this randomized, doubleblind trial, we assessed the efficacy and safety of. Ertapenem, the first of a new group of carbapenems. Invanz ertapenem is an antibiotic thats usually only given in hospital for serious infections.
A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Ertapenem, like imipenem and meropenem, demonstrates broadspectrum antimicrobial activity against many grampositive and. Ertapenem is extensively protein bound at 92% to 95%, followed by imipenemcilastatin at 20%, doripenem 8. Medline search from 1975 to 1997 and followup of references. Substitutes and alternatives to invanz ertapenem for uses like colorectal surgical site infection prophylaxis, community acquired pneumonia and diabetic foot infection without osteomyelitis. Imipenem and meropenem have an elimination halflife of approximately 1 h, are. Ertapenem versus cefotetan prophylaxis in elective. Compared with imipenem, meropenem and doripenem, the spectrum of activity of ertapenem is more limited primarily because it lacks activity against. Compare ampicillin vs ertapenem comprehensive analysis. The pooled odds ratio or with 95% credible interval cri was calculated by. Despite its narrower antimicrobial spectrum compared to imipenem and meropenem, ertapenem caused greater increases in gi colonization by c. Ertapenem binds to penicillin binding proteins pbps located on the bacterial cell wall, in particular pbps 2 and 3, thereby inhibiting the final transpeptidation step in the synthesis of peptidoglycan, an essential component of the bacterial cell wall.
Imipenem, meropenem, and doripenem are pharmacologically similar. Ertapenem, a longacting carbapenem, may be an alternative to the recommended prophylactic antibiotic cefotetan. The ftmics for the mouse and human dosing regimens agreed to within 10% at mics of. Ertapenem is a betalactam antibiotic of the carbapenem penem class with a broad spectrum of activity. Compared with imipenem, meropenem and doripenem, the spectrum of activity of ertapenem is more limited primarily because it lacks activity against pseudomonas aeruginosa and enterococcus spp. The rate of susceptibility to ertapenem and meropenem was limited and less than that to imipenem for the rgm. Imipenem, meropenem and doripenem have in vivo half lives of approximately 1 hour, while ertapenem has a halflife of approximately 4 hours making it. Comparative effects of ertapenem, imipenem, and meropenem. Merrem meropenem is an antibiotic thats usually only given in the hospital for serious infections.
Imipenem, meropenem and ertapenem are licensed in the european community and panipenem and biapenem are also available in japan and south korea. The mean ertapenem dot1,000 apds declined by approximately 68% compared to the preasi phase i 14. Listing a study does not mean it has been evaluated by the u. Comparative effects of ertapenem, imipenem, and meropenem on. Both groups were subsequently treated either with one carbapenem or with normal saline for 10 days. Carbapenem stewardship positive impact on hospital.
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